首发精神分裂症的心理韧性与临床康复：一项10年纵向研究比较临床康复者、未康复者与健康对照

ORIGINAL RESEARCH article

Front. Psychiatry

Sec. Social Psychiatry and Psychiatric Rehabilitation

• University of Oslo, Oslo, Norway

Abstract

Introduction: Research on resilience in clinical recovery following first-episode schizophrenia (FES) remains limited, and few longitudinal studies achieve sufficient retention to capture long-term trajectories. To address this, the Oslo Schizophrenia Recovery Study (OSR) was designed to examine resilience over time in FES. Investigating resilience is essential for understanding how individuals exposed to schizophrenia may achieve favorable outcomes. We addressed two primary questions: First, how does resilience change over time in individuals with FES compared with healthy controls. Second, whether longitudinal resilience trajectories within the FES group differ between participants who meet predefined clinical recovery criteria compared to those who do not. Methods: Repeated assessments were conducted across 12 clinical evaluations. The sample comprised 28 individuals with FES and 28 healthy controls. Resilience was measured with the Connor–Davidson Resilience Scale, and social and role functioning were indexed using the Global Functioning Scales. The data were analyzed using linear multilevel models. Candidate longitudinal mixed-effects models were compared using the small-sample corrected Akaike Information Criterion (AICc), with parameters estimated by maximum likelihood. Results: At 10-year follow-up, retention was 79%. Half of the FES group achieved clinical recovery. Model estimates indicated increasing resilience over time in the FES group, whereas resilience in healthy controls remained relatively stable, although statistical support for differential trajectories between groups was limited. Clinically recovered individuals showed a steeper increase in resilience. In contrast, non-recovered individuals exhibited only modest, gradual improvements, with resilience levels remaining lower at study completion. Conclusion: Different resilience trajectories were observed between clinically recovered and non‑recovered individuals with FES, with greater improvements in resilience associated with recovery. Although causality remains uncertain and differences to healthy controls were less robust, these findings highlight the value of repeated longitudinal assessments of resilience in FES, both to more precisely characterize resilience trajectories and to reduce drop‑out rates.

Keywords

First-episode psychosis, High retention, longitudinal study, prognosis, Recovery rate, resilience

Received

18 February 2026

Accepted

25 August 2026

Copyright

© 2026 Torgalsbøen, Mohn, Larøi and Czajkowski. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) or licensor are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

*Correspondence:

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